| Akademik Birim: |
Faculty of Engineering and Natural Sciences / Department of Bioinformatics & Genetics |
| Öğrenim Türü: |
Örgün Eğitim |
| Ön Koşullar |
yok |
| Öğrenim Dili: |
İngilizce |
| Dersin Düzeyi: |
Lisans |
| Dersin Koordinatörü: |
Ebru BİLGET GÜVEN |
| Dersi Veren(ler): |
Ebru BİLGET GÜVEN |
| Dersin Amacı: |
This course teaches the common organic functional groups that are important in biomolecules and explains how the chemical properties of these functional groups relate to their function. Moreover, it teaches the fundamental energetics of biochemical processes. The course content elaborates the metabolic pathways and the basics of their regulations in health and disease. |
| Dersin İçeriği: |
Carbohydrates, lipids and cell membranes, signal-transduction pathways, introduction to intermediary metabolism, major catabolic pathways, energy storage, basics of drug development |
| Dersin Öğrenme Çıktıları (ÖÇ): |
- 1- Understand the chemical structure of monosaccharides as the simplest carbohydrates, how they are linked to form complex carbohydrates and describe how carbohydrates can be attached to proteins.
- 2- Describe fatty acids, the key constituent of lipids. Define lipids and list the major kinds of membrane lipids. Describe how phospholipids and glycolipids readily form bimolecular sheets in aqueous media.
- 3- Distinguish between channels, carriers, and pumps. Examine how the transport of molecules across a membrane may be active or passive.
- 4- List the components of signal-transduction cascades. Summarize the physiological triggers of, and responses to, release of epinephrine, insulin, and epidermal growth factor. Draw a generalized molecular circuit based on a signal-transduction cascade.
- 5- Describe how a cell extracts energy and reducing power from its environment and synthesizes the macromolecules. Introduce ATP as the universal currency of free energy in biological systems.
- 6- Examine glycolysis, which is very tightly controlled, as an energy conversion pathway in many organisms. Explain how glucose can be synthesized from non-carbohydrate precursors.
- 7- Understand the citric acid cycle is the final common pathway for the oxidation of fuel molecules and serves as a source of building blocks for biosyntheses.
- 8- Describe how oxidative phosphorylation depends on electron transfer and takes place in mitochondria.
- 9- Understand the function of Pentose Phosphate Pathway and the key role of glucose-6-phosphate dehydrogenase in protection against reactive oxygen species.
- 10- Explain how glycogen is synthesized and degraded by different pathways and regulated reciprocally.
- 11- Discuss the challenges for drug development and describe ways through which drug candidates can be discovered. Delineate the stages of drug development.
|
| Dersin Öğrenme Yöntem ve Teknikleri |
The course content will be introduced by PowerPoint presentations during the lectures. The required and recommended materials will be uploaded to the KHAS Learn page of the course. JoVE platform, selected review/ research articles will be used to support the course content and help students to review the lecture and visualize the subject. Questions integrating the previously covered lectures into ongoing lecture content will allow students better understand how the concepts are related to each other. |
| Hafta | Konular | Ön Hazırlık |
ÖÇ |
| 1 |
Carbohydrates; Lipids and Cell Membranes |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
1, 2 |
| 2 |
Lipids and Cell Membranes; Membrane Channels and Pumps |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
2, 3 |
| 3 |
Signal Transduction Pathways |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
4 |
| 4 |
Metabolism: Basic Concepts and Design |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
4, 5 |
| 5 |
Glycolysis and Gluconeogenesis |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
6 |
| 6 |
Glycolysis and Gluconeogenesis |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
6 |
| 7 |
Midterm Exam Week |
The midterm exam will include everything covered in the lectures. The students are also responsible for the material uploaded to the KHAS Learn and the corresponding chapter content of the required textbook. |
1 - 6 |
| 8 |
The Citric Acid Cycle |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
7 |
| 9 |
The Citric Acid Cycle; Oxidative Phosphorylation |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
7, 8 |
| 10 |
Oxidative Phosphorylation |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
8 |
| 11 |
Pentose Phosphate Pathway; Glycogen Metabolism |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
9, 10 |
| 12 |
Glycogen Metabolism |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
10 |
| 13 |
Feast of Ramadan |
no lectures |
| 14 |
Drug Development |
The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. After the lecture hours, the required and recommended materials (to review the lectures) will be uploaded to the KHAS Learn. |
11 |
Kadir Has Üniversitesi'nde bir dönem 14 haftadır, 15. ve 16. hafta sınav haftalarıdır.
