COURSE DESCRIPTION AND APPLICATION INFORMATION
| Course Name | Code | Semester | T+A+L (hour/week) | Type (C / O) | Local Credit | ECTS |
|---|---|---|---|---|---|---|
| Molecular Basis of Cancer | MBG 421 | Spring | 03+00+00 | Compulsory | 3 | 5 |
| Academic Unit: | Molecular Biology and Genetics |
| Mode of Delivery: | Face to face |
| Prerequisites: | None |
| Language of Instruction: | English |
| Level of Course Unit: | Undergraduate |
| Course Coordinator: | - - |
| Course Objectives: | This course focuses on the molecular biology of cancer and introduces models and techniques used to study cancer. The hallmarks of cancer cells will be explained, and how they change the cellular processes and metabolic pathways will be analyzed. |
| Course Contents: | cancer genome, oncogenes, tumor suppressor genes, model organisms in cancer studies, cancer stem cells, cancer microenvironment, cell cycle in cancer cells, apoptosis, necrosis, autophagy, senescence, cancer metabolism, carcinogenesis, metastasis, angiogenesis |
| Learning Outcomes of the Course Unit (LO): |
|
| Planned Learning Activities and Teaching Methods: | PowerPoint presentations, which are also shared with the students through the KHAS Learn platform, will introduce the concepts. Watching mechanistic/explanatory videos during lectures and discussing with students. Discussion with the students during the lecture. Questions integrating the previously covered lectures into ongoing lecture content will allow students better understand how the concepts are related to each other. JoVE platform, selected review/ research articles will support the course content and help students review the lecture and visualize the subject. |
WEEKLY SUBJECTS AND RELATED PREPARATIONS
| Week | Subjects | Related Preperation |
|---|---|---|
| 1 | Cancer as a genetic disorder | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 2 | How to study cancer | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 3 | The cancer genome | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 4 | Oncogenes and tumor suppressor genes | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 5 | Epigenetics and cancer | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 6 | Cell cycle and its regulation | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 7 | Midterm Exam Week: The exact date/time will be announced later. | The midterm exam will include everything covered in the lectures. The students are also responsible for the material uploaded to the KHAS Learn and the corresponding chapter content of the required textbook. |
| 8 | Cancer metabolism | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 9 | Cell death mechanisms | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 10 | Cellular senescence | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 11 | Cancer stem cells and their microenvironment | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 12 | Metastasis and angiogenesis | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 13 | Inflammation and cancer | The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours. |
| 14 | Student Presentations | Students should be prepared according to the shared rules and format. |
At Kadir Has University, a Semester is 14 weeks; The weeks 15 and 16 are reserved for final exams.
REQUIRED AND RECOMMENDED READING
| The Molecular Basis of Cancer (Fourth Edition) by Mendelsohn, Gray, Howley, Israel, Thompson. ISBN-13: 978-1455740666 The research and review articles uploaded to the KHAS Learn are also required. |
OTHER COURSE RESOURCES
| JoVE Scientific Video Journal will be used to support the lecture visually. The links will be available on the KHAS Learn page of the course. Please activate your JOVE accounts in order to have full access to the links. Your KHAS e-mail and password will be your username and password, respectively. |
ASSESSMENT METHODS AND CRITERIA
| Semester Requirements | Number | Percentage of Grade (%) |
|---|---|---|
| Attendance / Participation | 14 | - |
| Presentation / Jury | 1 | 20 |
| Extra-Class Activities (reading, individual study etc.) | 10 | 20 |
| Midterms / Oral Exams / Quizes | 1 | 20 |
| Final Exam | 1 | 40 |
| Total: | 27 | 100 |
WORKLOAD
| Events | Count | Duration (Hours) | Total Workload (hour) |
|---|---|---|---|
| Course Hours | 14 | 3 | 42 |
| Preparation for Presentation / Jury | 1 | 20 | 20 |
| Extra-Class Activities (reading,individiual work, etc.) | 10 | 2 | 20 |
| Midterms / Oral Exams / Quizes | 1 | 20 | 20 |
| Final Exam | 1 | 23 | 23 |
| Total Workload (hour): | 125 | ||
1 ECTS = 25 Hours Workload
THE RELATIONSHIP BETWEEN COURSE LEARNING OUTCOMES (LO) AND PROGRAM QUALIFICATIONS (PQ)
| # | PQ1 | PQ2 | PQ3 | PQ4 | PQ5 | PQ6 | PQ7 | PQ8 | PQ9 |
| LO1 | |||||||||
| LO2 | |||||||||
| LO3 | |||||||||
| LO4 |
Contribution: 1 Low, 2 Average, 3 High