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COURSE DESCRIPTION AND APPLICATION INFORMATION

Course Name Code Semester T+A+L (hour/week) Type (C / O) Local Credit ECTS
Biochemistry II MBG 326 Spring 03+00+00 Compulsory 3 5
Academic Unit: Department of Molecular Biology & Genetics
Mode of Delivery: Face to face
Prerequisites: None
Language of Instruction: English
Level of Course Unit: Undergraduate
Course Coordinator: - -
Course Objectives: This course elaborates on the composition of carbohydrates and lipids to understand how their structural features are related to the functions they offer. We will focus on their chemical nature and principal biological roles. Adrenalin-, insulin-, and epidermal-growth-factor-initiated pathways will be used as examples to comprehend the fundamentals of signal transduction pathways. Students will first become familiar with the basic concepts and design of metabolism. Then, they will thoroughly examine the energy-producing, carbohydrate-utilizing metabolic pathways and study the integration of energy metabolism.
Course Contents: Carbohydrates, lipids, signal-transduction pathways, introduction to intermediary-metabolism, carbohydrate metabolism, integration of energy metabolism.
Learning Outcomes of the Course Unit (LO):
  • 1- Understand the chemical structure of monosaccharides as the simplest carbohydrates, how they are linked to form complex carbohydrates, and describe how carbohydrates can be attached to proteins.
  • 2- Acquire knowledge about the properties, nomenclature, and biological functions of lipid molecules.
  • 3- Describe the essential components of signal-transduction cascades. Summarize the physiological triggers of, and responses to, the release of epinephrine, insulin, and epidermal growth factor. Draw a generalized molecular circuit based on a signal-transduction cascade.
  • 4- Describe how a cell extracts energy and reducing power from its environment, and synthesizes the macromolecules. Introduce ATP as the universal currency of free energy in biological systems.
  • 5- Examine glycolysis, which is tightly controlled, as an energy conversion pathway in many organisms. Explain how glucose can be synthesized from non-carbohydrate precursors.
  • 6- Understand that the citric acid cycle is the final common pathway for the oxidation of fuel molecules and serves as a source of building blocks for biosynthesis.
  • 7- Describe how oxidative phosphorylation depends on electron transfer and takes place in mitochondria.
  • 8- Understand the function of the pentose phosphate pathway and the critical role of glucose-6-phosphate dehydrogenase in protection against reactive oxygen species.
  • 9- Explain how glycogen is degraded and synthesized by different pathways and regulated reciprocally.
  • 10- Assemble an integrated perspective of energy metabolism and a review of the fundamental themes of metabolism in mammalians.
Planned Learning Activities and Teaching Methods: PowerPoint presentations will introduce the course content during the lectures. The required and recommended materials will be uploaded to the KHAS Learn platform. Links to the recommended textbook, the JoVE platform, and selected review/research articles will support the course content and help students review the lecture and visualize the subject. Integrating the previously covered lectures into ongoing lecture content will allow students to understand better how the concepts are related. Quizzes, midterm, and final exams will be held as assessment methods.


WEEKLY SUBJECTS AND RELATED PREPARATIONS

WeekSubjectsRelated Preperation
1 Introduction to the Course & Introduction to Carbohydrates The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
2 Carbohydrates The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
3 Lipids The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
4 Signal Transduction The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
5 Introduction to Metabolism The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
6 Glycolysis The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
7 Midterm Exam Week: The exact date/time will be announced later. The midterm exam will include everything covered in the lectures. The students are also responsible for the material uploaded to the KHAS Learn and the corresponding chapter content of the required textbook.
8 Gluconeogenesis The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
9 Glycolysis and Gluconeogenesis The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
10 Citric Acid Cycle The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
11 Oxidative Phosphorylation The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
12 The Pentose Phosphate Pathway The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
13 Glycogen Degradation and Synthesis The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.
14 Integration of Energy Metabolism The students should read (from the required textbook) the chapter corresponding to the subject of the week before the lecture hours. The The students should follow the KHAS Learn pages to examine the assigned material before and after the lecture hours.


REQUIRED AND RECOMMENDED READING

Required Textbook:
Biochemistry (Ninth Edition)
Berg JM, Tymoczko JL, Gatto Jr. GJ, Stryer L, WH Freeman/Palgrave Macmillan International Higher Education ISBN-13: 978-1-319-11465-7
ISBN-10: 1-319-11465-2
The research and review articles uploaded to the KHAS Learn are also required.
Recommended Textbooks:
1) Human Metabolism: A Regulatory Perspective, 4th Edition
By Keith N. Frayn, Rhys Evans

2) Lehninger Principles of Biochemistry (Seventh Edition)
Nelson DL, Cox MM. WH Freeman/Palgrave Macmillan International Higher Education
ISBN-13: 978-1-4641-2611-6
ISBN-10: 1-4641-2611-9


OTHER COURSE RESOURCES

JoVE Scientific Video Journal will be used to support the lecture visually.
The links will be available on the KHAS Learn page of the course.
Please activate your JOVE accounts in order to have full access to the links.
Your KHAS e-mail and password will be your username and password, respectively.


ASSESSMENT METHODS AND CRITERIA

Semester RequirementsNumberPercentage of Grade (%)
Attendance / Participation 14 -
Midterms / Oral Exams / Quizes 17 65
Final Exam 1 35
Total: 32 100


WORKLOAD

EventsCountDuration (Hours)Total Workload (hour)
Course Hours14342
Extra-Class Activities (reading,individiual work, etc.)14342
Midterms / Oral Exams / Quizes171.525.5
Final Exam11515
Total Workload (hour):124.5


THE RELATIONSHIP BETWEEN COURSE LEARNING OUTCOMES (LO) AND PROGRAM QUALIFICATIONS (PQ)

# PQ1 PQ2 PQ3 PQ4 PQ5 PQ6 PQ7 PQ8 PQ9
LO1 2     2 2       2
LO2 2     2 2       2
LO3 2     2 2       2
LO4 2     2 2       2
LO5 2     2 2       2
LO6 2     2 2       2
LO7 2     2 2       2
LO8 2     2 2       2
LO9 2     2 2       2
LO10 2     2 2       2